Antiphospholipid Syndrome and Kidney Involvement: New Insights
نویسندگان
چکیده
Antiphospholipid syndrome is an autoimmune disorder characterized by vascular thromboses and pregnancy morbidity associated with antiphospholipid antibodies: lupus anticoagulant, IgG or IgM anticardiolipin or anti-beta 2-glycoprotein I. The kidney is one of the major target organs in antiphospholipid syndrome (APS). However, beyond the known involvement of the kidney in primary and associated APS, we may be observing a new form of APS within the context of renal failure. This review describes the classical kidney manifestations of APS and provides new considerations to be taken into account.
منابع مشابه
Antiphospholipid syndrome-associated nephropathy; a nephropathy needs classification
Antiphospholipid antibodies are known as a heterogeneous group of autoantibodies associated with the hypercoagulable condition affecting the vascular tree with thrombosis entitled antiphospholipid syndrome (1). Antiphospholipid syndrome is an autoimmune disorder with various etiology that contains cellular, genetic, molecular and pathogenic mechanisms. The antiphospholipid syndrome clinical cha...
متن کامل"Black swan in the kidney": renal involvement in the antiphospholipid antibody syndrome.
The antiphosphospholipid antibody syndrome (APS) describes a clinical entity with recurrent thrombosis, fetal loss, thrombocytopenia in the presence of lupus anticoagulant and/or antibodies to cardiolipin. These antibodies may be associated with connective tissue diseases such as systemic lupus erythematosus (secondary APS) or be found in isolation (primary APS). Renal syndromes increasingly be...
متن کاملRenal involvement in primary antiphospholipid syndrome: retrospective analysis of 160 patients.
BACKGROUND AND OBJECTIVES The objective of this study was to evaluate the prevalence, clinicopathologic features, and outcome of renal involvement in a large cohort of patients with primary antiphospholipid syndrome (PAPS). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We retrospectively examined medical records of 160 patients with a diagnosis of PAPS of two general hospitals of northern Ita...
متن کاملP-75: The Association of Antiphospholipid Syndrome and Recurrent Miscarriages
a:4:{s:10:"Background";s:364:"Antiphospholipid syndrome is a coagulation disorder that causes recurrent miscarriages and fetal deaths. In the present review we summarize current knowledge about Antiphospholipid syndrome that associated with recurrent miscarriages. In addition, on the basis of these comprehensive data, possible pathophysiologic mechanisms of this disorder are discussed.";s:19:"M...
متن کامل